Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy
نویسندگان
چکیده
منابع مشابه
Radiation induced non-targeted response: mechanism and potential clinical implications.
Generations of students in radiation biology have been taught that heritable biological effects require direct damage to DNA. Radiation-induced non-targeted/bystander effects represent a paradigm shift in our understanding of the radiobiological effects of ionizing radiation in that extranuclear and extracellular effects may also contribute to the biological consequences of exposure to low dose...
متن کاملResponse to criticism of the paper titled 'Non-targeted effects and radiation-induced carcinogenesis: a review'.
Exposure to ionising radiation is clearly associated with an increased risk of developing some types of cancer. However, the contribution of non-targeted effects to cancer development after exposure to ionising radiation is far less clear. The currently used cancer risk model by the international radiation protection community states that any increase in radiation exposure proportionately incre...
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hedgehog signalling pathway has not only a critical role in cell proliferation, differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. recent research has increased our understanding of this pathway and its relation to other signalling pathways. in addition, a large number of studies confirmed the alterati...
متن کاملNon-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects.
Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant r...
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ژورنال
عنوان ژورنال: Journal of Biomedical Physics and Engineering
سال: 2018
ISSN: 2251-7200
DOI: 10.31661/jbpe.v8i4dec.713